This document presents research on Call for Change Enhancement Upper Egyptian Females' Knowledge Regarding Effect of Female Genital Mutilation. The study was conducted to assess Upper Egyptian females' knowledge about FGM/C. Subject & Methods: A descriptive cross-sectional study was used. The study population consisted of 2837 females in family health centers (FHCs) in different sitting at Beni-Suef. Α Structured Interviewing Questionnaire sheet was used to collect data.